Demonstrates efficient synthesis of indole-derived atropisomers, indicating strong enantioselectivity.
A Rh(I)-catalyzed enantioselective C2-arylation of indole derivatives with aryl bromides is reported. In the presence of the Rh/chiral cyclohexyl-fused SPINOL-derived phosphoramidite complex, C2-arylation of indoles proceeded smoothly, affording a wide range of indole-C3 biaryl-type atropisomers in good yields and enantioselectivity (up to 98% yield, up to 92% ee) under mild conditions. This method displays good functional group tolerance.
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Yin et al. (2026) studied this question.
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