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May 25, 2026Genetics and Molecular BiologyOpen Access

LncRNAs as regulators of chemoresistance and chemosensitivity in triple-negative breast cancer

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Authors

MCMiguel Ángel Cáceres-DuránARAnna Carolina Lima RodriguesJAJuscelino Carvalho de Azevedo

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Overview

Review examines how lncRNAs influence chemoresistance and chemosensitivity in TNBC, suggesting new therapeutic and biomarker strategies.

Key Points

  • This review aims to investigate the role of long non-coding RNAs in regulating chemoresistance and chemosensitivity in triple-negative breast cancer.
  • Evaluated the biological functions of lncRNAs in TNBC and their molecular mechanisms.
  • Reviewed evidence linking lncRNAs to therapeutic resistance and sensitivity.
  • Explored potential of lncRNAs as biomarkers and therapeutic targets.
  • LncRNAs can either promote chemoresistance or enhance chemosensitivity through various mechanisms.
  • They regulate critical processes including epigenetics, DNA damage repair, apoptosis, and signaling pathways.
  • LncRNAs show promise as therapeutic targets and biomarkers for personalized treatment strategies.

Cite This Study

Cáceres-Durán et al. (2026) studied this question.

synapsesocial.com/papers/6a13e71a0e02ee3982d31dc4https://doi.org/10.1590/1678-4685-gmb-2025-0242
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