Sustainable Quinazoline Synthesis over a Novel Multifunctional CS‑NPs@MWCNT@CuFe₂O₄@Zeolite Catalyst

This study introduces a novel multifunctional catalyst, designated as CS-NPs@MWCNT@CuFe 2 O 4 @Zeolite, developed for the sustainable synthesis of quinazoline derivatives in aqueous media. The catalyst was synthesized through a meticulous multi-step process that integrates chitosan nanoparticles (CS-NPs), multi-walled carbon nanotubes (MWCNT), copper ferrite (CuFe 2 O 4 ), and zeolite, resulting in a composite material with enhanced catalytic properties. This catalyst exhibits remarkable stability and efficiency, successfully running the reaction over seven cycles, demonstrating significant activity. Characterization of the catalyst was performed using techniques such as FTIR, SEM, and XRD to confirm its structural integrity and composition. The performance of this catalyst was evaluated in the synthesis of 18 distinct quinazoline derivatives under mild reaction conditions at 50°C. Remarkably, the reactions yielded high product efficiencies, with yields ranging from 90% to 97%. The use of water as a solvent not only aligns with the principles of green chemistry but also promotes an efficient and environmentally friendly reaction environment. The multifunctional characteristics of the catalyst facilitate effective interactions with the reactants, thereby enhancing both reaction efficiency and selectivity. These findings underscore the potential of the CS-NPs@MWCNT@CuFe 2 O 4 @Zeolite catalyst as a promising alternative for sustainable organic synthesis, paving the way for future investigations into its application in other chemical transformations.