ABSTRACT Background: “Kobe dementia model” is a checkup system of dementia started from 2019. Many studies have shown that diabetes mellitus (DM) is a risk factor for the development of dementia. We examined the clinical characteristics of “Kobe dementia model” of Alzheimer’s disease (AD) with DM. We hypothesized that diabetic patients are younger and have more comorbidities than nondiabetic patients. Therefore, a check-up system for dementia in diabetic patients may have an effect on cognitive function, ADL, living environment, and use of long-term care insurance. Objectives: We examined the clinical characteristics of the “Kobe dementia model” for AD with DM in Kobe City. Methods: The study patients consisted of 165 ( n : DM 45 vs. NDM 120) patients. Current age, sex, Hasegawa Dementia Scale-Revised, HbA1c, ratio of living alone, use of long-term care insurance, and ratio of comorbidities were assessed. The patients were divided into two groups for analysis: the diabetic group and nondiabetic group. A cross-sectional analysis of the two groups was performed using Student’s t -test for continuous data. Furthermore, logistic regression analysis was then performed. Results: DM versus NDM (age: 81.4 ± 5.3 vs. 83.2 ± 5.0 years; P = 0.048, male: 48.9 vs. 30.0%; P = 0.024, Living alone: 8.9 vs. 30.0%; P = 0.005, Dyslipidemia: 62.2 vs. 39.2%; P = 0.008). Using independent factors associated with DM, logistic analysis was performed. Sex ( P = 0.031) and dyslipidemia ( P = 0.007) had significant correlations. On the other hand, living alone had negative correlations ( P = 0.012). Conclusion: The rate of comorbid dyslipidemia was higher in diabetic patients than in those without DM. Therefore, attention should be paid to comorbidity of dyslipidemia in AD patients with DM.
Yoshino et al. (2026) studied this question.