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This study investigates the association between diabetes mellitus and the risk of dementia and its subtypes in older adults.

October 12, 2004Neurology

Diabetes mellitus and risk of dementia in the Kungsholmen project

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This study investigates the association between diabetes mellitus and the risk of dementia and its subtypes in older adults.
Examined a cohort of 1,301 dementia-free community dwellers aged 75+ in Stockholm, Sweden over 6 years.
Utilized Cox proportional hazards models to analyze dementia incidence with adjustments for potential confounders.
Followed participants for a total of 5,584 person-years.
350 subjects developed dementia during follow-up, including 260 cases of Alzheimer disease and 49 cases of vascular dementia.
Diabetes was associated with HR of 1.5 (95% CI 1.0 to 2.1, p = 0.04) for dementia and 2.6 (95% CI 1.2 to 6.1) for vascular dementia.
Patients on oral antidiabetics had an HR of 1.7 (95% CI 1.0 to 2.8, p = 0.04) for dementia and 3.6 (95% CI 1.3 to 9.5) for vascular dementia.

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Longitudinal analysis reveals diabetes raises dementia risk in the elderly, indicating significant health implications.

Xu et al. (2004) studied this question.

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