Key result
A 10-ml/min/1.73 m2 lower estimated GFR (<60 ml/min/1.73 m2) was associated with increased cardiovascular mortality (IRR 1.29; 95% CI 1.06-1.55), as was a doubling of albuminuria.
Why the study?
Do decreased estimated GFR and albuminuria independently predict cardiovascular and all-cause mortality in the general US population?
Cohort (n=14,586)
Yes
Do decreased estimated GFR and albuminuria independently predict cardiovascular and all-cause mortality in the general US population?
Effect estimate: IRR 1.29 (95% CI 1.06-1.55)
Moderately decreased estimated GFR and albuminuria independently predict cardiovascular and all-cause mortality in the general population, supporting their combined use for risk stratification.
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Supports combined eGFR-albuminuria assessment for CV risk stratification in US adults; extends prior data yet leaves causal effects and practice change open.
Astor et al. (2008) conducted a cohort in General population (n=14,586). Decreased estimated GFR and albuminuria was evaluated on Cardiovascular and all-cause mortality (IRR 1.29, 95% CI 1.06-1.55). A 10-ml/min/1.73 m2 lower estimated GFR (<60 ml/min/1.73 m2) was associated with increased cardiovascular mortality (IRR 1.29; 95% CI 1.06-1.55), as was a doubling of albuminuria.
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