Hypertension in pregnancy as a risk factor for cardiovascular disease later in life
Key result
A history of hypertension in pregnancy independently increased the risk of subsequent stroke compared to no such history (12% vs 5%; adjusted HR 2.10; 95% CI 1.19-3.71; P=0.01).
Why the study?
Does a history of hypertension in pregnancy increase the risk of subsequent hypertension, CHD, and stroke in women?
Population
4,782 women who participated in the Phase 2 (2000-2004) Family Blood Pressure Program study
Comparison
History of hypertension in at least one pregnancy vs Women with no history of hypertension in pregnancy
Design
Cohort
Authors
Discussion
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Implication
Supports targeted stroke surveillance after hypertensive pregnancy; leaves open prospective validation and intervention trials.
Study Design
Type
Cohort (n=4,782)
Structured PICO
Does a history of hypertension in pregnancy increase the risk of subsequent hypertension, CHD, and stroke in women?
P
Population
4,782 women who participated in the Phase 2 (2000-2004) Family Blood Pressure Program study
I
Intervention
History of hypertension in at least one pregnancy
C
Comparator
Women with no history of hypertension in pregnancy
O
Outcome
Subsequent diagnoses of hypertension, coronary heart disease (CHD), and strokehard clinical
Main Result
Effect estimate: HR 2.10 (95% CI 1.19-3.71)
Absolute Event Rate: 12% vs 5%
p-value: p=0.01
Hypertension in pregnancy is an independent risk factor for the subsequent development of hypertension and stroke later in life.
Cite This Study
Garovic et al. (2010) conducted a cohort in Hypertension in pregnancy (n=4,782). History of hypertension in pregnancy vs. No history of hypertension in pregnancy was evaluated on Subsequent diagnosis of stroke (HR 2.10, 95% CI 1.19-3.71, p=0.01). A history of hypertension in pregnancy independently increased the risk of subsequent stroke compared to no such history (12% vs 5%; adjusted HR 2.10; 95% CI 1.19-3.71; P=0.01).