Key result
Cardiac resynchronization therapy for chronic heart failure is an established treatment, with current advancements primarily focused on reducing the clinical problem of non-responders.
Why the study?
Despite increasing CRT implantations for heart failure with reduced cardiac function and wide QRS, the presence of non-responders remains a problem.
This review outlines the evolution of CRT, current Japanese guideline indications, and strategies such as automated optimization and AF management to improve responder rates.
CRT optimization strategies may aid clinicians; leaves open prospective validation of responder-rate improvements.
QRS幅の広い心機能の低下した心不全症例に対する植込み型デバイス治療として，心臓再同期療法（cardiac resynchronizationtherapy： CRT）は確立された治療法であり，日本循環器学会ガイドラインにおいては，心不全の程度，左脚ブロックの有無，QRS幅，洞調律の有無，ペーシング依存の有無によってCRTの適応が細かく決められている．我が国においては2006年に保険償還され，年々植込み数が増加しているが，CRTに反応しないnon-responderの存在が問題となっている．ここでは，CRT治療の歴史，ガイドライン適応と，non-responderを減らすための進化した現在のCRT治療について概説する．
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Kengo Kusano (2019) studied this question. Cardiac resynchronization therapy for chronic heart failure is an established treatment, with current advancements primarily focused on reducing the clinical problem of non-responders.
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