What is the clinical evidence from this study?

Study design: Review. Population: Atherosclerosis and Atrial Fibrillation. Intervention: Direct factor Xa and thrombin inhibitors.

What question did this study set out to answer?

To review the non-hemostatic cellular signaling mediated by factor Xa and thrombin through protease-activated receptors and assess the broader therapeutic effects of direct anticoagulants.

January 2, 2014Cardiovascular ResearchOpen Access

Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants

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Key result

Direct factor Xa and thrombin inhibition may modulate cellular processes involved in atherosclerosis and atrial fibrillation beyond their primary role in coagulation.

Design

Review

Authors

HSHenri M.H. SpronkVascular Medicine AJAnne Marye de JongUtrecht University HCHarry J. CrijnsElectrophysiology

Discussion

Member takes

Implication

May support pleiotropic effects of direct anticoagulants; hypothesis-generating for atherosclerosis and AF, requiring prospective trials.

Key Points

To review the non-hemostatic cellular signaling mediated by factor Xa and thrombin through protease-activated receptors and assess the broader therapeutic effects of direct anticoagulants.
Narrative synthesis evaluating mechanistic evidence on protease-activated receptor (PAR) signaling activated by factor Xa and thrombin.
Investigation of cellular pathways influencing early atherogenesis, atrial fibrillation pathogenesis, and hypercoagulability.
Factor Xa and thrombin activate PAR-mediated intracellular pathways that contribute directly to early vascular inflammation and atherosclerosis.
Upregulated PAR expression and activation link hypercoagulability to pro-arrhythmic cellular remodeling in atrial fibrillation.
Direct pharmacological inhibition of factor Xa and thrombin provides pleiotropic vascular protection independently of traditional anticoagulation pathways.

Structured PICO

Intervention

Direct factor Xa and thrombin inhibitors

Direct factor Xa and thrombin inhibitors may offer pleiotropic benefits beyond anticoagulation by modulating PAR-mediated cellular processes in atherosclerosis and atrial fibrillation.

Cite This Study

Spronk et al. (2014) conducted a review in Atherosclerosis and Atrial Fibrillation. Direct factor Xa and thrombin inhibitors was evaluated. Direct factor Xa and thrombin inhibition may modulate cellular processes involved in atherosclerosis and atrial fibrillation beyond their primary role in coagulation.

synapsesocial.com/papers/6a1404d52398cfa26a893fdb https://doi.org/10.1093/cvr/cvt343

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF

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Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider