Key result
Hypertension linked to adverse shifts in metabolic, lipid, and renal biomarkers.
Why the study?
Hypertension is a major public health problem in developing countries like Ethiopia, increasing morbidity and mortality, requiring assessment of biochemical parameters to prevent complications.
Does hypertension associate with altered fasting blood glucose, serum electrolytes, renal function, and lipid profiles in adults?
Cross-Sectional (n=156)
No
Does hypertension associate with altered fasting blood glucose, serum electrolytes, renal function, and lipid profiles in adults?
Hypertensive patients exhibit significant biochemical alterations in glucose, lipid profile, renal function, and electrolytes compared to healthy controls, highlighting the need for regular biochemical monitoring.
Answers are grounded in this paper and cite their sources.
Hypertension was associated with adverse metabolic and renal profiles; leaves open whether monitoring improves outcomes in prospective studies.
Background Hypertension is a silent killer that requires long term management to avoid complications. It is one of major public health problem in developing counties like Ethiopia. Hypertension increases the risk of morbidity and mortality and has negative consequences on the cognitive and physical fitness of productivity in adults. Objective To assess fasting blood glucose, serum electrolyte, albumin, creatinine, urea, and lipid profile among hypertensive patients and non-hypertensive participants at wolaita sodo teaching and referral hospital. Methods A comparative cross-sectional study was conducted from December 2019 to February 2020. On the study a total of 156 study participants (78 cases and 78 controls) were involved. Each study participant, after signing informed consent, interviewed about the socio-demographic and anthropometric characteristic features. Then 5ml of the blood sample was collected from each 78 patients with hypertension and each 78 samples from apparently healthy subjects from WSUTRH during the period. Fasting blood glucose, serum electrolyte, albumin, creatinine, urea, and lipid profile level were measured in each group. The Data were analyzed by using Epi data version 3.1 and SPSS version 21.0 software (IBM Corporation, USA) and results were summarized using means and percentages and presented by using figures and tables. P-value < 0.05 was considered to be significant at 95% confidence level. Any abnormal laboratory results of study subjects dispatched and communicated with physicians for better management. Results The mean age of hypertensives and control study groups were 50 ± 10.0 and 51 ±11.3 years respectively. The body mass index of hypertensives and control study groups were 53.4% and 34.2% overweighed respectively. The mean ± SD of fasting blood glucose, total cholesterol, LDL-C, TG, RFT were significantly increases while serum sodium, calcium, albumin, and HDL-Cholesterol significantly decreased in hypertensives when compared with non-hypertensives and serum potassium was no statistical significance among case and control groups. Conclusion In present study, we observed that the hypertensive group was at risk for developing biochemical alteration in creatinine, urea, fasting blood glucose, lipid profile, electrolytes, and albumin test parameters with an increased period of time. Recommendation Regular measurements of biochemical parameters strongly needed for hypertensive patients.
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Haile et al. (2020) conducted a cross-sectional in Hypertension (n=156). Hypertension vs. Non-hypertensive participants was evaluated on Fasting blood glucose, serum electrolyte, albumin, creatinine, urea, and lipid profile. Hypertension was associated with significantly increased fasting blood glucose, total cholesterol, LDL-C, triglycerides, and renal function tests, and decreased sodium, calcium, albumin, and HDL-C.
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