Cardiovascular and renal protective role of angiotensin blockade in hypertension with advanced CKD: a subgroup analysis of ATTEMPT-CVD randomized trial

Figures

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  Figure 1. Kaplan-Meier curves for composite cardiovascular and renal events during the follow-up period in patients with eGFR of <45 ml/min per 1.73 m2 and/or UACR of ≥300 mg/g creatinine (a) and the other patients (b). In (a), the numbers of patients in ARB and non-ARB groups were 96 and 91, respectively, and the number of occurrence of endpoints was 11 and 22 in ARB group and non-ARB group, respectively. In (b), the number of endpoints was 27 in 516 patients assigned ARB group and 29 in 518 patients assigned non-ARB group. Abbreviations: G3b and/or A3, patients with estimated glomerular filtration rate of <45 ml/min per 1.73 m2 and/or urinary albumin/creatinine ratio of ≥300 mg/g creatinine; The other, patients with both estimated glomerular filtration rate of ≥45 ml/min per 1.73 m2 and urinary albumin/creatinine ratio of <300 mg/g creatinine; ARB, antihypertensive treatment with angiotensin II receptor blocker; Non-ARB, treatment with antihypertensive drugs except for angiotensin II receptor blocker; HR, hazard ratio; 95%CI, 95% confidence interval.

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  Figure 2. Time course of % changes in urinary albumin/creatinine ratio (UACR) in ARB and non-ARB groups in patients with eGFR of <45 ml/min per 1.73 m2 and/or UACR of ≥300 mg/g creatinine (a) and the other patients (b). Abbreviations used are the same as in Fig. 1. Values are mean ± SD.

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  Figure 3. Time course of changes in estimated glomerular filtration rate (eGFR) in ARB and non-ARB groups in patients with eGFR of <45 ml/min per 1.73 m2 and/or UACR of ≥300 mg/g creatinine (a) and the other patients (b). Abbreviations used are the same as in Fig. 1. Values are mean ± SD.

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  Figure 4. Time course of % changes in plasma brain natriuretic peptide (BNP) in ARB and non-ARB groups in patients with eGFR of <45 ml/min per 1.73 m2 and/or UACR of ≥300 mg/g creatinine (a) and the other patients (b). Abbreviations used are the same as in Fig. 1. Values are mean ± SD.

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  Figure 5. Time course of systolic and diastolic blood pressure (BP) in ARB and non-ARB groups in patients with eGFR of <45 ml/min per 1.73 m2 and/or UACR of ≥300 mg/g creatinine (a) and the other patients (b). Abbreviations used are the same as in Fig. 1. Values are mean ± SD.