Frailty Trajectories After Treatment for Coronary Artery Disease in Older Patients
Key result
Coronary artery disease treatment was associated with a U-shaped frailty trajectory, with frailty index scores improving at 6 months and worsening at 12 and 30 months (P<0.001 over time).
Why the study?
Does the trajectory of frailty differ by treatment modality (CABG, PCI, medical therapy) and age in older patients with coronary artery disease?
Population
374 older patients undergoing nonemergent cardiac catheterization followed by treatment for coronary artery…
Comparison
Coronary artery disease treatment vs Comparisons between treatment groups and by…
Design
Cohort
Follow-up
30 months
Authors
Discussion
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Member takes
Implication
CAD treatment may yield only transient frailty gains; leaves open whether revascularization sustains benefits versus medical therapy by age.
Study Design
Type
Cohort (n=374)
Structured PICO
Does the trajectory of frailty differ by treatment modality (CABG, PCI, medical therapy) and age in older patients with coronary artery disease?
P
Population
374 older patients undergoing nonemergent cardiac catheterization followed by treatment for coronary artery disease
I
Intervention
Coronary artery disease treatment (CABG [n=128], PCI [n=150], or medical therapy only [n=96])
C
Comparator
Comparisons between treatment groups (CABG vs PCI vs medical therapy) and by age/sex
O
Outcome
Frailty index (FI) score trajectory at 6, 12, and 30 months after treatment
Main Result
p-value: p=<0.001
Frailty follows a U-shaped trajectory after CAD treatment, with patients under 75 experiencing sustained frailty reduction after revascularization compared to medical therapy alone.
Cite This Study
Freiheit et al. (2016) conducted a cohort in Coronary artery disease (n=374). Coronary artery disease treatment (CABG or PCI) vs. Medical therapy only was evaluated on Frailty index (FI) score trajectory (p=<0.001). Coronary artery disease treatment was associated with a U-shaped frailty trajectory, with frailty index scores improving at 6 months and worsening at 12 and 30 months (P<0.001 over time).