Key result
High D-dimer in AMI patients is linked to ~134% higher mortality and increased HF risk.
Why the study?
Few studies have explored the association between baseline D-dimer levels and the incidence of HF and all-cause mortality in an AMI population.
Are elevated baseline D-dimer levels associated with an increased incidence of heart failure and all-cause mortality in patients with acute myocardial infarction?
Population
4504 consecutive patients with AMI
Comparison
Baseline plasma D-dimer levels on admission across quartiles
Design
Prospective cohort study
Follow-up
Median of 1 year
Authors
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Elevated D-dimer may refine post-AMI risk stratification; leaves open whether it informs interventions or improves outcomes.
Cohort (n=4,504)
Are elevated baseline D-dimer levels associated with an increased incidence of heart failure and all-cause mortality in patients with acute myocardial infarction?
Effect estimate: HR 2.34 (95% CI 1.33-4.13)
p-value: p=<0.001
Elevated baseline D-dimer levels on admission in AMI patients are associated with an increased risk of subsequent heart failure and all-cause mortality over a 1-year follow-up.
Zhang et al. (2020) conducted a cohort in Acute myocardial infarction (n=4,504). High plasma D-dimer levels on admission (Quartile 4) vs. Low plasma D-dimer levels on admission (Quartile 1) was evaluated on All-cause mortality (HR 2.34, 95% CI 1.33-4.13, p=<0.001). High baseline D-dimer levels (Q4 vs Q1) in AMI patients were associated with increased risks of heart failure after hospitalization (HR 1.49) and death (HR 2.34; 95% CI 1.33-4.13; p<0.001).
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