What question did this study set out to answer?

To evaluate the blood-sparing efficacy and mechanism of action of high-dose aprotinin during primary myocardial revascularization.

December 1, 1990AnesthesiologyOpen Access

Influence of High-dose Aprotinin Treatment on Blood Loss and Coagulation Patterns in Patients Undergoing Myocardial Revascularization

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Authors

WDW. DietrichUniversitätsklinikum Tulln MSM. SpannaglJohn Innes Centre MJMarianne JochumGoethe University Frankfurt

Discussion

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Implication

Randomized trial reveals reduced blood loss and transfusion needs in myocardial revascularization patients, indicating high-dose aprotinin preserves hemostasis.

Key Points

To evaluate the blood-sparing efficacy and mechanism of action of high-dose aprotinin during primary myocardial revascularization.
Randomized, placebo-controlled trial in 40 patients undergoing primary myocardial revascularization.
The intervention group received an initial bolus of 2 × 10^6 kallikrein inactivator units (KIU) of aprotinin preoperatively, followed by a continuous infusion of 5 × 10^5 KIU/h during surgery and 2 × 10^6 KIU in the cardiopulmonary bypass pump prime.
Total blood loss was reduced from 1,431 ± 760 ml in the control group to 738 ± 411 ml in the aprotinin group (P < 0.05).
Homologous blood requirement decreased from 838 ± 963 ml (2.3 ± 2.2 U) in controls to 163 ± 308 ml (0.63 ± 0.96 U) with aprotinin (P < 0.05), with 63% of treated patients avoiding banked blood compared to 25% of controls.
Activated clotting time before heparinization was significantly longer in the aprotinin group (141 ± 13 s vs. 122 ± 25 s) and remained elevated until post-bypass heparin neutralization.

Cite This Study

Dietrich et al. (1990) studied this question.

synapsesocial.com/papers/6a14236e2ecb6dc541896b4e https://doi.org/10.1097/00000542-199012000-00009

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Implication

Randomized trial reveals reduced blood loss and transfusion needs in myocardial revascularization patients, indicating high-dose aprotinin preserves hemostasis.

Influence of High-dose Aprotinin Treatment on Blood Loss and Coagulation Patterns in Patients Undergoing Myocardial Revascularization

Discussion

Member takes

Implication

Key Points

Cite This Study

Influence of High-dose Aprotinin Treatment on Blood Loss and Coagulation Patterns in Patients Undergoing Myocardial Revascularization

Discussion

Member takes

Implication

Key Points

Cite This Study

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