Why the study?
Does aprotinin reduce bleeding and improve haematological variables in cardiac surgery patients who bleed significantly post-operatively?
Population
60 cardiac surgery patients who bled in excess of 400 ml in the first 3 h post-operatively and had not…
Comparison
Aprotinin in addition to conventional treatment vs Placebo in addition to conventional treatment
Design
RCT, randomised, double-blind
Follow-up
until discharge
Authors
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Supports aprotinin rescue therapy in significant post-cardiac surgery bleeding; confirms reduced loss and platelet preservation in RCT.
Does aprotinin reduce bleeding and improve haematological variables in cardiac surgery patients who bleed significantly post-operatively?
Aprotinin administered as a rescue therapy to cardiac surgery patients with significant post-operative bleeding reduces blood loss and improves platelet adhesion.
Kallis et al. (1994) studied this question.
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