Key result
Non-compliance with medical prescriptions occurred in approximately 62% of patients with chronic heart failure and was associated with frontal cognitive impairment (58%) and memory impairment (40%).
Why the study?
What factors are associated with cognitive impairment and non-compliance in patients with chronic heart failure?
Observational (n=189)
What factors are associated with cognitive impairment and non-compliance in patients with chronic heart failure?
Non-compliance in heart failure patients is highly prevalent and strongly associated with specific structural brain changes and cognitive impairments, which correlate with worse cardiac function.
May warrant cognitive screening in nonadherent heart failure; leaves open causal direction and intervention effects in prospective studies.
AIM: To determine the factors of cognitive impairment and non-compliance in patients with chronic heart failure (CHF). MATERIAL AND METHODS: One hundred and fifty-seven patients with CHF and 32 patients without chronic heart failure (controls) were examined. Neuropsychological assessment using a 30-minutes protocol recommended by NINDS-Canadian Stroke Standards (NINDS CSS), magnetic resonance imaging, cognitive ERP and a test of compliance were used. RESULTS AND CONCLUSION: Approximately 62% of patients did not perform medical prescriptions. Non-compliance was associated with an increase in the severity of subcortical and perivenricular leukoaraiosis, a slowdown in decision-making processes (an increase in the P300 latency), worse performance on speech activity tests, optical/spatial and frontal dysfunctions and memory. Patients with non-compliance had frontal cognitive impairment (58%), memory impairment (40%) and mixed forms (21%). Cognitive impairment in patients with chronic heart failure was associated with the lower left ventricular ejection fraction and deterioration in indices of diastolic function.
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Shestakova et al. (2017) conducted an observational in Chronic heart failure (n=189). Non-compliance with medical prescriptions occurred in approximately 62% of patients with chronic heart failure and was associated with frontal cognitive impairment (58%) and memory impairment (40%).
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