Evolution of influenza A virus nucleoprotein genes: implications for the origins of H1N1 human and classical swine viruses
Key result
Phylogenetic analysis of 89 influenza A virus nucleoprotein genes indicates that H1N1 human and classical swine viruses share a single avian-like common ancestor dating to between 1912 and 1918.
Population
52 published and 37 new nucleoprotein (NP) gene sequences of human and swine influenza A viruses
Design
Other
Authors
Discussion
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Member takes
Implication
Supports avian-like 1918 H1N1 ancestor in humans and swine; hypothesis-generating for viral evolution studies.
Structured PICO
P
Population
52 published and 37 new nucleoprotein (NP) gene sequences of human and swine influenza A viruses
I
Intervention
Phylogenetic analysis
O
Outcome
Evolution and origin of human and swine influenza A viruses
Phylogenetic analysis suggests that H1N1 human and classical swine viruses share an avian-like common ancestor from around 1918, which likely caused the severe human influenza pandemic before entering swine populations.
Limitations
- The analysis cannot reveal the original host
Cite This Study
Gorman et al. (1991) studied Influenza A virus (n=89). Phylogenetic analysis of 89 influenza A virus nucleoprotein genes indicates that H1N1 human and classical swine viruses share a single avian-like common ancestor dating to between 1912 and 1918.