Key result
Among older women with hypertension, calcium channel blocker monotherapy was associated with a greater risk of CVD death compared to diuretics (HR 1.55; 95% CI 1.02-2.35).
Why the study?
Does the choice of antihypertensive drug class (monotherapy or combination) affect the risk of cardiovascular mortality and events in postmenopausal women with hypertension and no prior CVD?
Population
30,219 postmenopausal women aged 50 to 79 years with hypertension but no history of cardiovascular disease.
Comparison
Antihypertensive monotherapy or 2-drug-class… vs Other antihypertensive monotherapies or…
Design
Cohort
Follow-up
mean 5.9 years
Authors
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May warrant caution with CCB monotherapy versus diuretics in older hypertensive women; leaves open optimal regimens pending randomized confirmation.
Cohort (n=30,219)
Yes
Does the choice of antihypertensive drug class (monotherapy or combination) affect the risk of cardiovascular mortality and events in postmenopausal women with hypertension and no prior CVD?
Effect estimate: HR 1.55 (95% CI 1.02-2.35)
In postmenopausal women with hypertension, diuretic monotherapy is equal or superior to other monotherapies, and combining a calcium channel blocker with a diuretic is associated with higher CVD mortality compared to a beta-blocker plus diuretic.
Sylvia Wassertheil‐Smoller (2004) conducted a cohort in Hypertension (n=30,219). Calcium channel blockers (monotherapy or combined with diuretics) vs. Diuretics (monotherapy or combined with beta-blockers) was evaluated on CVD mortality (HR 1.55, 95% CI 1.02-2.35). Among older women with hypertension, calcium channel blocker monotherapy was associated with a greater risk of CVD death compared to diuretics (HR 1.55; 95% CI 1.02-2.35).
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