Effectiveness of Rotarix® vaccine in Africa in the first decade of progressive introduction, 2009-2019:  systematic review and meta-analysis

Figures

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  Figure 1.. Identification of studies included in the systematic review. VE=Vaccine effectiveness.

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  Figure 2.. Forest plot of vaccine effectiveness of full and partial doses against hospitalization for rotavirus gastroenteritis. Studies are plotted starting with the earliest published to the recent. Each study is represented by a black box and a horizontal line, which correspond to the odds ratio and 95% CI, respectively. The vertical line in the middle corresponds to an odds ratio of 1.0. The diamond represents the overall pooled odds ratio with the 95% CI given by its width. I-squared shows the degree of heterogeneity with p-value indicating whether there was statistically significant heterogeneity between the studies and among the groups. Fulldose stands for two doses of the Rotarix while Partial represents one dose of Rotarix.

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  Figure 3.. Forest plot of vaccine effectiveness against hospitalization for rotavirus gastroenteritis stratified by age groups. Studies are plotted starting with the earliest published to the recent. Each study is represented by a black box and a horizontal line, which correspond to the odds ratio and 95% CI, respectively. The vertical line in the middle corresponds to an odds ratio of 1.0. The diamond represents the overall pooled odds ratio with the 95% CI given by its width. I-squared shows the degree of heterogeneity with p-value indicating whether there was statistically significant heterogeneity between the studies and among the groups.

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  Figure 4.. Funnel plot to assess publication bias among studies evaluating effectiveness of RV1 vaccine against hospitalization for laboratory-confirmed rotavirus gastroenteritis. The triangle represents the estimates of the included studies that reported on the effectiveness of full and partial dose of RV1 vaccine. The log of the odds ratio is plotted on the horizontal axis, against the standard error of the log odds ratio. The vertical line in the funnel plot indicates the random effect summary estimate and the sloping two lines indicate the expected 95% CIs for a given SE.