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April 20, 2017Clinical Infectious Diseases

Effectiveness of Rotavirus Vaccination: A Systematic Review of the First Decade of Global Postlicensure Data, 2006–2016

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Why the study?

Do rotavirus vaccines (RV1 and RV5) prevent rotavirus disease in children globally?

Population

Children from 24 countries across geographic regions and with different child mortality levels

Design

Systematic_review

Authors

CJChristine L. JonestellerCenters for Disease Control and PreventionEBEleanor BurnettNational Center for Immunization and Respiratory DiseasesCYCatherine YenNational Institutes of Health

Discussion

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Member takes

Implication

Rotavirus vaccines show substantial effectiveness across mortality settings; confirms postlicensure benefit and supports global routine immunization.

Structured PICO

Do rotavirus vaccines (RV1 and RV5) prevent rotavirus disease in children globally?

P
Population
Children from 24 countries across geographic regions and with different child mortality levels (data from 48 peer-reviewed articles)
I
Intervention
Rotavirus vaccines (Rotarix/RV1 and RotaTeq/RV5)
O
Outcome
Vaccine effectiveness against rotavirus disease

Postlicensure data from the first decade demonstrates that both RV1 and RV5 are effective against rotavirus disease across different child mortality settings, supporting WHO recommendations for routine immunization.

Cite This Study

Jonesteller et al. (2017) studied this question.

synapsesocial.com/papers/69de5ceea051b8e25be93dc3https://doi.org/10.1093/cid/cix369
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness and impact of rotavirus vaccines in the United States – 2006–20122014 · 95 citations
  2. 2Effectiveness of Monovalent and Pentavalent Rotavirus Vaccines in Guatemala2016 · 35 citations
  3. 3Effectiveness of rotavirus vaccines, licensed but not funded, against rotavirus hospitalizations in the Valencia Region, Spain2015 · 36 citations
  4. 4Sustained Effectiveness of Rotavirus Vaccine Against Very Severe Rotavirus Disease Through the Second Year of Life, Bolivia 2013–20142016 · 33 citations
  5. 5Effectiveness of Monovalent Rotavirus Vaccine After Programmatic Implementation in Botswana: A Multisite Prospective Case-Control Study2016 · 76 citations