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January 6, 2014Expert Review of VaccinesOpen Access

Effectiveness and impact of rotavirus vaccines in the United States – 2006–2012

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Why the study?

Do rotavirus vaccines prevent severe gastroenteritis in US children?

Population

US children <5 years of age, as well as older age groups ineligible for vaccination

Design

Review

Follow-up

7 years (2006-2012)

Authors

BRBrian RhaCenters for Disease Control and PreventionJTJacqueline E. TateWisconsin Department of Health ServicesDPDaniel C. PayneCincinnati Children's Hospital Medical Center

Discussion

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Implication

Sustains US rotavirus vaccination programs; extends herd-immunity evidence but leaves open durability and strain-shift monitoring.

Structured PICO

Do rotavirus vaccines prevent severe gastroenteritis in US children?

P
Population
US children <5 years of age, as well as older age groups ineligible for vaccination
I
Intervention
Rotavirus vaccines (RotaTeq [RV5] and Rotarix [RV1])
O
Outcome
Severe gastroenteritis / severe diarrheal diseasehard clinical

Rotavirus vaccines have been highly effective in reducing severe gastroenteritis in the US, providing both direct protection to vaccinated children and indirect herd immunity to older, unvaccinated groups.

Cite This Study

Rha et al. (2014) studied this question.

synapsesocial.com/papers/6a7e7612dea41f5fbab7b97dhttps://doi.org/10.1586/14760584.2014.877846
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Epidemiology Of Rotavirus Diarrhea In The United States: Surveillance And Estimates Of Disease Burden1996 · 355 citations
  2. 2Monovalent Rotavirus Vaccine Provides Protection Against an Emerging Fully Heterotypic G9P[4] Rotavirus Strain in Mexico2011 · 80 citations
  3. 3Effectiveness of Monovalent and Pentavalent Rotavirus Vaccine2013 · 122 citations
  4. 4Rotavirus Vaccine and Health Care Utilization for Diarrhea in U.S. Children2011 · 166 citations
  5. 5Infant Rotavirus Vaccination May Provide Indirect Protection to Older Children and Adults in the United States2011 · 189 citations