Key result
Increased deviation angle of the intercusp triangle is associated with impaired aortic root geometry and aortic regurgitation (OR 1.3; 95% CI 1.114-1.350; p<0.0001).
Why the study?
Is the deviation angle of the intercusp triangle associated with impaired aortic root geometry and aortic regurgitation?
Observational (n=123)
Is the deviation angle of the intercusp triangle associated with impaired aortic root geometry and aortic regurgitation?
Effect estimate: OR 1.3 (95% CI 1.114-1.350)
p-value: p=<0.0001
An increased deviation angle of intercusp triangles is associated with impaired coaptation of aortic valve leaflets, suggesting that restoration of this angle to 1.7±1.2° is geometrically necessary for normal valve function.
Increased intercusp triangle deviation was associated with aortic regurgitation in this animal model; hypothesis-generating for geometric restoration in human aortic valve repair.
AIM: To assess linear and geometric parameters of the aortic valve and to determine the changes which are associated with impaired leaflets coaptation and aortic root enlargement. MATERIAL AND METHODS: Surgical anatomy of the aortic root and its spatial relationships with surrounding heart structures were studied with plastination by using of combined silicon technologies. 123 specimens of the aortic root with preserved original geometry were created with silicone plastination technique and perfusion embalming. Analysis included 15 heart specimens with the signs of aortic root dilatation and 108 specimens without evidence of dilatation. Multiple logistic regression was used for statistical analysis. RESULTS: Anatomical and clinical analysis showed that deviation angle of the intercusp triangle is the factor contributing impaired aortic root geometry and aortic regurgitation (OR 1.3, 95% CI 1.114-1.350, p<0.0001). CONCLUSION: 1) Increased deviation angle of intercusp triangles is associated with impaired coaptation of aortic valve leaflets. 2) Restoration of intercusp triangle deviation angle within 1.7±1.2° degrees is geometrically necessary to achieve normal function of the aortic valve.
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Хубулава et al. (2018) conducted an observational in Aortic regurgitation and aortic root enlargement (n=123). Increased deviation angle of the intercusp triangle vs. Normal deviation angle was evaluated on Impaired aortic root geometry and aortic regurgitation (OR 1.3, 95% CI 1.114-1.350, p=<0.0001). Increased deviation angle of the intercusp triangle is associated with impaired aortic root geometry and aortic regurgitation (OR 1.3; 95% CI 1.114-1.350; p<0.0001).
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