Modulation of Cytokine-Induced Cardiac Myocyte Apoptosis by Nitric Oxide, Bak, and Bcl-x
Population
Neonatal cardiac myocytes in serum-free culture
Design
Preclinical
Follow-up
72 hours
Authors
Discussion
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Member takes
Implication
NO synthase inhibition blocks cytokine-induced myocyte apoptosis in vitro; leaves open relevance to human inflammatory cardiomyopathy.
Structured PICO
P
Population
Neonatal cardiac myocytes in serum-free culture
I
Intervention
Macrophage-derived cytokines (interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma) or NO donor S-nitrosoglutathione
O
Outcome
Cardiac myocyte apoptosis and necrosissurrogate
Cytokine-induced toxicity in neonatal cardiac myocytes is driven by nitric oxide production and subsequent apoptosis, modulated by the balance of Bak and Bcl-x(L).
Cite This Study
Ing et al. (1999) studied this question.