February 1, 2000Cardiovascular ResearchOpen Access

Tumor necrosis factor-α induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes

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Why the study?

Does TNF-alpha induce apoptosis via iNOS in neonatal mouse cardiomyocytes?

Population

Neonatal cardiac myocytes isolated from iNOS (-/-) mutant and C57BL6 wild type mice

Comparison

Treatment with an NO donor or tumor necrosis… vs Comparison between wild type and iNOS mutant…

Design

Preclinical

Authors

WSWei SongDalian Medical University

Discussion

Member takes

Implication

Should not yet inform clinical decisions; extends evidence for iNOS-dependent TNF-alpha apoptosis in murine cardiomyocytes.

Structured PICO

Does TNF-alpha induce apoptosis via iNOS in neonatal mouse cardiomyocytes?

Population

Neonatal cardiac myocytes isolated from iNOS (-/-) mutant and C57BL6 wild type mice

Intervention

Treatment with an NO donor (S-nitroso-N-acetyl-penicillamine [SNAP]) or tumor necrosis factor-alpha (TNF-alpha)

Comparator

Comparison between wild type and iNOS (-/-) mutant cardiomyocytes

Outcome

Apoptosis measured by TUNEL staining and cell death detection ELISAsurrogate

TNF-alpha induces apoptosis in neonatal mouse cardiomyocytes through an iNOS-dependent mechanism, highlighting a specific pathway for myocardial cell death.

Cite This Study

Wei Song (2000) studied this question.

synapsesocial.com/papers/6a705a5c26a7f98052dcdb55 https://doi.org/10.1016/s0008-6363(99)00395-8

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Tumor necrosis factor-α induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tumor necrosis factor-α induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider