Key result
Norepinephrine induced apoptosis in neonatal rat cardiomyocytes in a dose- and time-dependent manner through a ROS-TNF-caspase signaling pathway.
Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a ROS-TNF-caspase signaling pathway, providing mechanistic insights into heart failure pathogenesis.
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Identifies TNF-ROS-caspase axis in NE apoptosis; leaves open whether pathway inhibition alters HF progression in vivo.
Yun‐Ching Fu (2004) studied Norepinephrine-induced apoptosis in cardiomyocytes. Norepinephrine was evaluated on Apoptosis of cardiomyocytes. Norepinephrine induced apoptosis in neonatal rat cardiomyocytes in a dose- and time-dependent manner through a ROS-TNF-caspase signaling pathway.
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