Key result
Norepinephrine exposure increased the percentage of apoptotic adult rat ventricular myocytes from 5.8% to 21.0% (P<0.01), an effect mediated by the beta-adrenergic pathway and protein kinase A.
Why the study?
Does norepinephrine stimulate apoptosis in adult rat ventricular myocytes in vitro?
Does norepinephrine stimulate apoptosis in adult rat ventricular myocytes in vitro?
Absolute Event Rate: 21% vs 5.8%
p-value: p=<0.01
Norepinephrine stimulates apoptosis in adult rat ventricular myocytes via the beta-adrenergic pathway, suggesting a cellular mechanism contributing to the progression of myocardial failure.
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May promote myocyte loss in heart failure models; leaves open relevance to human disease progression.
Communal et al. (1998) studied Heart failure (in vitro model). Norepinephrine vs. Control was evaluated on Percentage of apoptotic cells (TUNEL staining) (p=<0.01). Norepinephrine exposure increased the percentage of apoptotic adult rat ventricular myocytes from 5.8% to 21.0% (P<0.01), an effect mediated by the beta-adrenergic pathway and protein kinase A.
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