Why the study?
Does in vivo treatment with norepinephrine induce delayed cardioprotection against postischemic dysfunction in the rat heart?
Population
Rats (in vivo treatment, isolated hearts perfused with modified Langendorff technique)
Comparison
Norepinephrine evaluated at 2 or 24 h after… vs Saline control
Design
Preclinical
Follow-up
24 hours
Authors
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Does not support clinical use; extends preclinical evidence of delayed adrenergic cardioprotection in rats.
Does in vivo treatment with norepinephrine induce delayed cardioprotection against postischemic dysfunction in the rat heart?
In vivo treatment with norepinephrine induces delayed cardioprotection against postischemic myocardial dysfunction in rats, likely mediated by alpha-1 adrenoceptors and associated with upregulation of c-fos and HSP70.
Xianzhong Meng (1996) studied this question.
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