Why the study?
Does atrial natriuretic peptide induce apoptosis in neonatal rat cardiac myocytes?
Population
Neonatal rat cardiac myocytes and non-myocytes in culture
Comparison
Atrial natriuretic peptide (ANP) up to 1 microM vs Control cultures
Design
Preclinical
Authors
Loading...
ANP-induced myocyte apoptosis in neonatal rats is hypothesis-generating; human relevance and therapeutic implications remain untested.
Does atrial natriuretic peptide induce apoptosis in neonatal rat cardiac myocytes?
ANP specifically induces apoptosis in cultured cardiac myocytes via a cGMP-dependent mechanism, an effect that is opposed by norepinephrine.
Wu et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: