Key result
Atrial natriuretic peptide (0.003 nm) inhibited Angiotensin II-stimulated proliferation in fetal sheep right ventricular cardiomyocytes by 68%.
Why the study?
Does atrial natriuretic peptide inhibit angiotensin II-stimulated proliferation in fetal sheep cardiomyocytes?
Does atrial natriuretic peptide inhibit angiotensin II-stimulated proliferation in fetal sheep cardiomyocytes?
Effect estimate: 68% inhibition
Atrial natriuretic peptide suppresses Angiotensin II-stimulated proliferation in fetal sheep cardiomyocytes, likely via a cGMP-dependent mechanism that inhibits MAPK and PI3K pathways.
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Hypothesis-generating in fetal sheep; human studies needed before clinical relevance.
O’Tierney et al. (2010) studied Fetal cardiomyocyte proliferation. Atrial natriuretic peptide (ANP) vs. Angiotensin II alone was evaluated on 48-hour 5-bromodeoxyuridine (BrdU) uptake (68% inhibition). Atrial natriuretic peptide (0.003 nm) inhibited Angiotensin II-stimulated proliferation in fetal sheep right ventricular cardiomyocytes by 68%.
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