Key result
Exogenous ANP significantly decreased cell number and DNA synthesis of embryonic cardiac progenitor cells, an effect reversed by the NPRA receptor-specific inhibitor A71915.
Why the study?
Does ANP signaling modulate proliferation and differentiation of embryonic cardiac progenitor cells?
Does ANP signaling modulate proliferation and differentiation of embryonic cardiac progenitor cells?
ANP plays a local paracrine role in developing mammalian ventricles by regulating the balance between cardiac progenitor cell proliferation and differentiation via NPRA/cGMP signaling.
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May modulate embryonic cardiac progenitor proliferation in mammals; leaves open relevance to human cardiac development or regeneration.
Hotchkiss et al. (2015) studied Embryonic ventricular myocardium development. Exogenous ANP was evaluated on Cell number and DNA synthesis of cardiac progenitor cells. Exogenous ANP significantly decreased cell number and DNA synthesis of embryonic cardiac progenitor cells, an effect reversed by the NPRA receptor-specific inhibitor A71915.
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