Why the study?
Does chronic pressure overload induce cardiomyocyte apoptosis and alter bax/bcl-2 gene expression in a rat model?
Population
Rat model of chronic pressure overload induced by transverse aortic constriction
Comparison
Transverse aortic constriction vs Sham-operated controls (SH)
Design
Preclinical
Follow-up
18 weeks
Authors
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Apoptosis may mediate rat LVH-to-LVD transition; hypothesis-generating and leaves open human relevance.
Does chronic pressure overload induce cardiomyocyte apoptosis and alter bax/bcl-2 gene expression in a rat model?
In a rat model of chronic pressure overload, cardiomyocyte-specific apoptosis and an altered bcl-2/bax ratio contribute to the transition from left ventricular hypertrophy to dysfunction.
Condorelli et al. (1999) studied this question.
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