Key result
Transverse aortic constriction in mice induced early concentric and late eccentric hypertrophy with LV dysfunction, associated with downregulated survival signaling and increased apoptosis.
Population
Mice subjected to transverse aortic constriction (TAC) or sham operation
Comparison
Transverse aortic constriction for 1-16 weeks vs Sham operation
Design
Preclinical
Follow-up
1 to 16 weeks
Authors
Loading...
Supports survival signaling downregulation as HF transition mechanism in pressure overload; hypothesis-generating, requires translational validation before clinical consideration.
Downregulation of survival signaling pathways (ERK1/2, Akt, GSK3beta) and increased apoptosis are key mechanisms in the transition from compensated cardiac hypertrophy to heart failure in a pressure-overload mouse model.
Li et al. (2009) studied pressure overload-induced cardiac hypertrophy to heart failure. Transverse aortic constriction (TAC) vs. sham operation was evaluated on LV dimensions, contractile function, and molecular markers of apoptosis and survival signaling. Transverse aortic constriction in mice induced early concentric and late eccentric hypertrophy with LV dysfunction, associated with downregulated survival signaling and increased apoptosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: