Key result
Transverse aortic constriction induced heart failure in female mice without a significant difference in the number of left ventricular cardiomyocytes or apoptotic nuclei compared to sham operation.
Population
female C57BL/6 wild-type mice
Comparison
transverse aortic constriction (TAC) vs sham-operated mice
Design
Preclinical
Follow-up
up to 6 weeks
Authors
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Suggests cardiomyocyte loss is dispensable for pressure-overload HF transition in female mice; hypothesis-generating and requires validation before clinical translation.
Cardiomyocyte loss is not required for the transition from compensated hypertrophy to heart failure induced by pressure overload in female mice.
Schipke et al. (2016) studied Left ventricular hypertrophy and heart failure. Transverse aortic constriction (TAC) vs. Sham-operated mice was evaluated on Number of left ventricular cardiomyocytes. Transverse aortic constriction induced heart failure in female mice without a significant difference in the number of left ventricular cardiomyocytes or apoptotic nuclei compared to sham operation.
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