Key result
Beta blockers linked to benefit in HCM, though effectiveness drops with increased LVOT.
Why the study?
The study was conducted to determine the efficacy of beta adrenergic blockers against hypertrophic cardiomyopathy.
Do beta blockers improve clinical parameters in patients with hypertrophic cardiomyopathy?
Observational (n=110)
No
Do beta blockers improve clinical parameters in patients with hypertrophic cardiomyopathy?
Beta blockers are effective in hypertrophic cardiomyopathy, but their efficacy is significantly reduced in patients with significant left ventricular outflow tract obstruction (LVOT ≥50mmHg).
Beta blockers may aid HCM without marked LVOT obstruction; observational data leaves open need for RCTs to confirm efficacy.
Objective: To determine the efficacy of beta adrenergic blockers against hypertrophic cardiomyopathy. Study Design: Retrospective study Place and Duration of Study: Khyber Teaching Hospital Peshawar from 1st April 2021 to 30th September 2021. Methodology: All the data was retrieved from the medical files of the patients who were registered as out/indoor patients at cardiology department. The sample size for this study was taken as 110 patients and age was between 5-76 years. Each patient complete information regarding age, gender, clinical history, comorbidity history, clinical symptoms, clinical assessment results, echo and ECG results was documented on a well-structured questionnaire. Patients were given beta blockers for two-year time and the effectiveness of various beta blockers was recorded. Results: There were 57.27% males while 42.73% were females. Patients where increased left ventricle outflow-tract such as LVOT was observed the efficiency of beta blocker was significantly reduced. A value of LVOT ≥50mmHg was presented in patients of the later ages while LVOT <50mmHg was seen in young and pediatric cases. Conclusion: Beta adrenergic blockers showed great effectiveness against hypertrophy cardiomyopathy.
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Yousaf et al. (2022) conducted an observational in Hypertrophic cardiomyopathy (n=110). Beta adrenergic blockers was evaluated on Effectiveness of beta blockers. Beta adrenergic blockers demonstrated effectiveness against hypertrophic cardiomyopathy over two years, though efficacy was significantly reduced in patients with increased left ventricular outflow tract.
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