Key result
Pro-active risk-guided management in chest pain clinics lowers absolute CV risk by ~3 percentage points.
Why the study?
To evaluate whether a pro-active, absolute cardiovascular risk-guided approach could opportunistically modify cardiovascular risk factors in patients presenting to a chest pain clinic without coronary ischaemia.
Does a pro-active, absolute cardiovascular risk-guided approach improve 5-year absolute cardiovascular risk scores in patients without coronary ischaemia attending a chest pain clinic?
Comparison
Pro-active absolute cardiovascular risk-guided management vs control
Design
Prospective, randomised, open label, blinded endpoint study
Follow-up
At least 12 months
Authors
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Supports proactive risk-guided care in chest pain clinics; extends absolute CV risk strategies to evaluated patients without ischaemia.
RCT (n=189)
open label, blinded endpoint
randomised
No
Does a pro-active, absolute cardiovascular risk-guided approach improve 5-year absolute cardiovascular risk scores in patients without coronary ischaemia attending a chest pain clinic?
Effect estimate: difference 2.7 percentage points (95% CI 1.2-4.1)
Absolute Event Rate: -2.4% vs 0.4%
An opportunistic, absolute cardiovascular risk-guided management strategy in a chest pain clinic significantly improved 5-year absolute cardiovascular risk scores compared to standard care.
Black et al. (2021) conducted an RCT in patients without coronary ischaemia attending a chest pain clinic (n=189). pro-active, absolute cardiovascular risk-guided approach to modifying risk factors vs. control group was evaluated on change in 5-year absolute risk score at follow-up (difference 2.7 percentage points, 95% CI 1.2-4.1). A pro-active, absolute cardiovascular risk-guided management strategy in a chest pain clinic significantly improved 5-year absolute cardiovascular risk scores by 2.7 percentage points (95% CI, 1.2-4.1).
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