Key result
Unfavorable cardiovascular health at baseline was associated with a significantly greater risk of coronary artery calcium progression (OR 2.43; 95% CI 1.40-4.23; P=0.0017).
Why the study?
Does an unfavorable cardiovascular health profile increase the incidence of coronary artery calcium progression in individuals with a baseline CAC score of zero?
Cohort (n=1,119)
Does an unfavorable cardiovascular health profile increase the incidence of coronary artery calcium progression in individuals with a baseline CAC score of zero?
Effect estimate: OR 2.43 (95% CI 1.40-4.23)
p-value: p=0.0017
An unfavorable cardiovascular health profile is associated with a significantly higher risk of coronary artery calcium progression over 6 years in individuals with initially zero CAC.
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May inform CVH counseling in zero-CAC adults; hypothesis-generating, prospective trials needed before practice change.
Hwang et al. (2018) conducted a cohort in Low-Risk Men and Women with zero Agatston CAC score (n=1,119). Unfavorable cardiovascular health vs. Favorable cardiovascular health was evaluated on CAC progression (increase in Agatston CAC score to ≥3.4) (OR 2.43, 95% CI 1.40-4.23, p=0.0017). Unfavorable cardiovascular health at baseline was associated with a significantly greater risk of coronary artery calcium progression (OR 2.43; 95% CI 1.40-4.23; P=0.0017).
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