Prospective validation of the Bleeding Academic Research Consortium classification in the all-comer PRODIGY trial
Key result
BARC Type 3 or 5 bleeding was associated with increased 2-year mortality (adjusted HR 7.72; 95% CI 4.75-12.54), providing a similar mortality risk assessment to TIMI or GUSTO scales.
Why the study?
Does the BARC bleeding classification predict mortality similarly to TIMI and GUSTO scales in patients undergoing percutaneous coronary intervention?
Population
Patients undergoing percutaneous coronary intervention in the all-comer PRODIGY trial
Comparison
Bleeding Academic Research Consortium bleeding… vs Thrombolysis in Myocardial Infarction and Global…
Design
Cohort, Prospectively adjudicated by a blinded Clinical Event Committee
Follow-up
2 years
Authors
Discussion
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Member takes
Implication
BARC may aid post-PCI mortality stratification similarly to TIMI/GUSTO; leaves open need for prospective validation before practice change.
Study Design
Type
Observational
Blinding
Blinded Clinical Event Committee
Structured PICO
Does the BARC bleeding classification predict mortality similarly to TIMI and GUSTO scales in patients undergoing percutaneous coronary intervention?
P
Population
Patients undergoing percutaneous coronary intervention in the all-comer PRODIGY trial
I
Intervention
Bleeding Academic Research Consortium (BARC) bleeding classification
C
Comparator
Thrombolysis in Myocardial Infarction (TIMI) and Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) bleeding scales
O
Outcome
2-year mortalityhard clinical
Main Result
Effect estimate: HR 7.72 (95% CI 4.75-12.54)
The BARC bleeding classification provides similar prognostic value for 2-year mortality as the established TIMI and GUSTO scales in patients undergoing percutaneous coronary intervention.
Cite This Study
Vranckx et al. (2014) conducted an observational in Percutaneous coronary intervention. BARC bleeding classification vs. TIMI and GUSTO bleeding scales was evaluated on 2-year mortality (HR 7.72, 95% CI 4.75-12.54). BARC Type 3 or 5 bleeding was associated with increased 2-year mortality (adjusted HR 7.72; 95% CI 4.75-12.54), providing a similar mortality risk assessment to TIMI or GUSTO scales.