Key result
Cholinergic blockade with glycopyrrolate augmented the blood pressure response to isometric handgrip exercise (+13 vs +3 mmHg; P<0.05) by abolishing the fall in systemic vascular resistance.
Why the study?
Does cholinergic blockade with glycopyrrolate alter the blood pressure and systemic vascular resistance responses at the onset of isometric handgrip or leg cycling exercise in young healthy males?
Population
17 young healthy males (n=9 for protocol 1 [isometric handgrip], n=8 for protocol 2 [leg cycling])
Comparison
Cholinergic blockade with glycopyrrolate during… vs Control conditions during the same exercise…
Design
Other
Authors
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Supports cholinergic vasodilation in isometric exercise BP control in healthy males; leaves open clinical translation or relevance to patients.
Does cholinergic blockade with glycopyrrolate alter the blood pressure and systemic vascular resistance responses at the onset of isometric handgrip or leg cycling exercise in young healthy males?
p-value: p=<0.05
A cholinergic mechanism contributes significantly to the blood pressure and systemic vascular resistance responses at the onset of isometric handgrip exercise, but not leg cycling, in humans.
Vianna et al. (2015) studied Healthy (n=17). Cholinergic blockade (glycopyrrolate) vs. Control (no drug) was evaluated on Blood pressure and systemic vascular resistance (p=<0.05). Cholinergic blockade with glycopyrrolate augmented the blood pressure response to isometric handgrip exercise (+13 vs +3 mmHg; P<0.05) by abolishing the fall in systemic vascular resistance.
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