What is the clinical evidence from this study?

Study design: Other. Intervention: Sustained handgrip (SHG) vs. Rest. Primary outcome: Muscle blood flow (measured by 133Xenon washout from the extensor carpi radialis longus muscle) (p=< 0.05).

What question did this study set out to answer?

To determine whether reflex increases in systemic arterial pressure preserve local blood flow within contracting skeletal muscle during sustained handgrip exercise.

December 1, 1993Acta Physiologica Scandinavica

The exercise pressor response to sustained handgrip does not augment blood flow in the contracting forearm skeletal muscle

Q: What are the key findings of this study?

Sustained handgrip at 30% and 45% of maximal voluntary contraction abolished exercise-induced hyperaemia in the active muscle despite large increases in mean arterial pressure.

Q: What question did this study set out to answer?

To determine whether reflex increases in systemic arterial pressure preserve local blood flow within contracting skeletal muscle during sustained handgrip exercise.

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Key result

Sustained handgrip abolishes exercise-induced hyperaemia in active muscle despite large increases in mean arterial pressure.

P<0.05

Why the study?

Does the exercise pressor response to sustained handgrip augment blood flow in the contracting forearm skeletal muscle?

Population

Subjects undergoing sustained handgrip exercise (demographics and sample size not specified in abstract)

Comparison

Sustained handgrip at 15%, 30%, and 45% of… vs Rest (baseline)

Design

Other

Follow-up

3 minutes

Authors

JHJ.W. HansenUniversity of Copenhagen TJT N JacobsenUniversity of Copenhagen OAOle AmtorpUniversity of Copenhagen

Discussion

Member takes

Implication

Challenges prior assumptions on pressure-driven muscle perfusion during intense isometric exercise; hypothesis-generating for local vascular regulation mechanisms.

Key Points

To determine whether reflex increases in systemic arterial pressure preserve local blood flow within contracting skeletal muscle during sustained handgrip exercise.
Measured 133Xenon washout from the extensor carpi radialis longus muscle to determine active muscle blood flow.
Monitored systemic arterial pressure and local muscle perfusion simultaneously across 3 minutes of sustained handgrip at 15%, 30%, and 45% of maximal voluntary contraction (MVC).
At 15% MVC, muscle blood flow increased more than 20-fold from baseline rest (P < 0.05), while mean arterial pressure rose by only 12 ± 4 mmHg.
At 30% and 45% MVC, exercise-induced hyperemia was completely abolished despite marked increases in mean arterial pressure of 29 ± 3 mmHg and 54 ± 5 mmHg, respectively.

Structured PICO

Does the exercise pressor response to sustained handgrip augment blood flow in the contracting forearm skeletal muscle?

Population

Subjects undergoing sustained handgrip exercise (demographics and sample size not specified in abstract)

Intervention

Sustained handgrip (SHG) at 15%, 30%, and 45% of maximal voluntary contraction (MVC) for 3 minutes

Comparator

Rest (baseline)

Outcome

Time-dependent changes in systemic arterial pressure and blood flow in the active muscle (extensor carpi radialis longus) measured by 133Xenon washoutsurrogate

Main Result

p-value: p=< 0.05

At handgrip levels above 15% MVC, reflex increases in blood pressure do not augment blood flow in the active skeletal muscle, challenging previous concepts based on whole-forearm measurements.

Cite This Study

Hansen et al. (1993) studied this question. Sustained handgrip (SHG) vs. Rest was evaluated on Muscle blood flow (measured by 133Xenon washout from the extensor carpi radialis longus muscle) (p=< 0.05). Sustained handgrip at 30% and 45% of maximal voluntary contraction abolished exercise-induced hyperaemia in the active muscle despite large increases in mean arterial pressure.

synapsesocial.com/papers/6aa35aa104de40c43bb1419f https://doi.org/10.1111/j.1748-1716.1993.tb09638.x

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Implication

Challenges prior assumptions on pressure-driven muscle perfusion during intense isometric exercise; hypothesis-generating for local vascular regulation mechanisms.

The exercise pressor response to sustained handgrip does not augment blood flow in the contracting forearm skeletal muscle

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

The exercise pressor response to sustained handgrip does not augment blood flow in the contracting forearm skeletal muscle

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider