Key result
Femoral arterial ATP infusion increased leg blood flow and interstitial norepinephrine (P<0.05) without changing interstitial ATP, suggesting vasodilatory effects are mediated via endothelial receptors.
Why the study?
Does arterial ATP infusion and exercise alter leg muscle interstitial ATP and norepinephrine concentrations in healthy men?
Does arterial ATP infusion and exercise alter leg muscle interstitial ATP and norepinephrine concentrations in healthy men?
p-value: p=<0.05
The vasodilatory and sympatholytic effects of intraluminal ATP appear to be mainly mediated via endothelial purinergic receptors rather than by altering local interstitial ATP concentrations.
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No immediate clinical application; leaves open endothelial purinergic targeting in vascular disease research.
Mortensen et al. (2009) studied Healthy (n=10). Femoral arterial ATP infusion and one-leg knee-extensor exercise vs. Baseline and control leg was evaluated on Muscle interstitial ATP and norepinephrine concentrations (p=<0.05). Femoral arterial ATP infusion increased leg blood flow and interstitial norepinephrine (P<0.05) without changing interstitial ATP, suggesting vasodilatory effects are mediated via endothelial receptors.
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