Key result
Obesity is linked to severe COVID-19 outcomes through immune system impairment.
Why the study?
Although diabetes, hypertension, cardiovascular disease, and renal failure are recognized risk factors for COVID-19, obesity was not yet well-considered despite impairing the adaptive immune system.
Does obesity increase the risk of severe outcomes in COVID-19 by impair the immune system?
Obesity is highlighted as a significant risk factor that impairs the immune system and contributes to severe outcomes in COVID-19.
Warrants enhanced monitoring for obese COVID-19 patients; leaves open mechanistic trials to confirm immune impairment.
An influenza-like virus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19 disease and spread worldwide within a short time. COVID-19 has now become a significant concern for public health. Obesity is highly prevalent worldwide and is considered a risk factor for impairing the adaptive immune system. Although diabetes, hypertension, cardiovascular disease (CVD), and renal failure are considered the risk factors for COVID-19, obesity is not yet well-considered. The present study approaches establishing a systemic association between the prevalence of obesity and its impact on immunity concerning the severe outcomes of COVID-19 utilizing existing knowledge. Overall study outcomes documented the worldwide prevalence of obesity, its effects on immunity, and a possible underlying mechanism covering obesity-related risk pathways for the severe outcomes of COVID-19. Overall understanding from the present study is that being an immune system impairing factor, the role of obesity in the severe outcomes of COVID-19 is worthy.
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Amin et al. (2021) conducted a review in COVID-19. Obesity was evaluated on Severe outcomes of COVID-19. Obesity acts as an immune system impairing factor and is a significant risk factor for severe outcomes of COVID-19.
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