Association Between Pulse Pressure and C-Reactive Protein Among Apparently Healthy US Adults
Key result
A 10 mm Hg increase in pulse pressure was associated with a 15% increase in the odds of having an elevated C-reactive protein level among healthy US adults (OR 1.15; 95% CI 1.01-1.31; P=0.04).
Why the study?
Is elevated pulse pressure associated with increased C-reactive protein levels in apparently healthy adults?
Population
9867 healthy persons 17 years of age or older who participated in the Third National Health and Nutrition…
Design
Cross-sectional
Authors
Discussion
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Implication
May link pulse pressure to inflammation in healthy adults; hypothesis-generating and should not yet change practice.
Study Design
Type
Cross-Sectional (n=9,867)
Multicenter
Yes
Structured PICO
Is elevated pulse pressure associated with increased C-reactive protein levels in apparently healthy adults?
P
Population
9867 healthy persons 17 years of age or older who participated in the Third National Health and Nutrition Examination Survey (US adults)
I
Intervention
Pulse pressure (evaluated per 10 mm Hg increase)
O
Outcome
Elevated C-reactive protein level (≥ 0.66 mg/dL)surrogate
Main Result
Effect estimate: OR 1.15 (95% CI 1.01 to 1.31)
p-value: p=0.04
Increases in pulse pressure are independently associated with elevated C-reactive protein levels among healthy US adults, suggesting inflammation may link pulse pressure to cardiovascular risk.
Cite This Study
Abramson et al. (2002) conducted a cross-sectional in Healthy adults (n=9,867). Pulse pressure was evaluated on Elevated C-reactive protein level (>= 0.66 mg/dL) (OR 1.15, 95% CI 1.01 to 1.31, p=0.04). A 10 mm Hg increase in pulse pressure was associated with a 15% increase in the odds of having an elevated C-reactive protein level among healthy US adults (OR 1.15; 95% CI 1.01-1.31; P=0.04).