Key result
Direct contact with beating myocardium reduced myogenic tone of coronary microvessels by approximately 40% (P < 0.05), an effect mediated by ATP-sensitive potassium channels.
Population
Pressurized isolated coronary vessels of rabbits placed on beating hearts of anesthetized dogs
Comparison
Direct contact with beating myocardium vs No contact
Design
Preclinical
Authors
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Myocardial contact may modulate coronary tone via KATP; leaves open translation to human basal resistance.
p-value: p=<0.05
The beating myocardium counteracts coronary microvessel myogenic tone by releasing transferable vasoactive signals mediated by the activation of K(ATP) channels.
Takeda et al. (2006) studied Myogenic tone of coronary microvessels (n=33). Direct contact with beating myocardium vs. Without contact (plastic film between vessel and heart) was evaluated on Myogenic tone reduction (p=<0.05). Direct contact with beating myocardium reduced myogenic tone of coronary microvessels by approximately 40% (P < 0.05), an effect mediated by ATP-sensitive potassium channels.
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