Key result
Endothelin exerts a tonic constrictor influence through the ET(A) receptor at low myocardial metabolic demand, but this influence decreases during increased metabolism.
Population
Isolated rat myocytes, isolated coronary arterioles, and chronically instrumented swine
Comparison
Endothelin type A (ET) receptor blockade and… vs Baseline/unstimulated state and before ET blockade
Design
Preclinical
Authors
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Suggests demand-dependent ET(A) coronary effects; hypothesis-generating for human vasoregulation studies.
Endothelin-1 exerts a tonic constrictor effect on coronary vasculature at rest, but its influence diminishes during increased metabolic demand such as exercise.
Merkus et al. (2002) studied Coronary vascular tone. Endothelin type A (ET(A)) receptor blockade and metabolic stimulation vs. Resting state / without blockade was evaluated on Coronary vasodilation. Endothelin exerts a tonic constrictor influence through the ET(A) receptor at low myocardial metabolic demand, but this influence decreases during increased metabolism.
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