December 1, 1988AJP Heart and Circulatory Physiology
Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension
Key result
Monocrotaline injection in rats induced early endothelial injury by day 4, followed by smooth muscle extension by day 8, and increased baseline pulmonary artery pressure by day 12 (P<0.01).
Population
Awake, unsedated male Sprague-Dawley rats (200-250 g)
Comparison
Monocrotaline (MC) injection (60 mg/kg) vs Saline vehicle injection
Design
Preclinical
Follow-up
12 days
Authors
Discussion
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Implication
Highlights early endothelial injury as potential window in rat PH model; leaves open human translation.
Structured PICO
P
Population
Awake, unsedated male Sprague-Dawley rats (200-250 g)
I
Intervention
Monocrotaline (MC) injection (60 mg/kg)
C
Comparator
Saline vehicle injection
O
Outcome
Hemodynamic response (pulmonary artery pressure and resistance) to acute hypoxia (10% O2 for 10 min) at 4, 8, and 12 days postinjectionsurrogate
Monocrotaline-induced pulmonary hypertension in rats is preceded by early endothelial injury and followed by increased pulmonary vascular reactivity and smooth muscle extension.
Cite This Study
Rosenberg et al. (1988) studied Monocrotaline-induced pulmonary hypertension. Monocrotaline vs. Saline vehicle was evaluated on Hemodynamic response to acute hypoxia, endothelial injury, and muscularization of pulmonary arteries. Monocrotaline injection in rats induced early endothelial injury by day 4, followed by smooth muscle extension by day 8, and increased baseline pulmonary artery pressure by day 12 (P<0.01).