Why the study?
Does an abdominal aortocaval shunt worsen survival and haemodynamics in male Wistar rats with monocrotaline-induced pulmonary hypertension?
Population
Male Wistar rats injected with monocrotaline (rat model for pulmonary hypertension)
Comparison
Creation of an abdominal aortocaval shunt to… vs Nonshunted monocrotaline rats
Design
Preclinical
Follow-up
4-5 weeks
Authors
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Increased pulmonary flow worsens experimental PH outcomes in rats; leaves open relevance to human shunt-associated disease.
Does an abdominal aortocaval shunt worsen survival and haemodynamics in male Wistar rats with monocrotaline-induced pulmonary hypertension?
In a rat model of pulmonary hypertension, increased pulmonary blood flow via aortocaval shunt worsened morbidity, mortality, and right heart failure without altering intra-acinar vessel remodeling.
Albada et al. (2005) studied this question.
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