Key result
Surgical aortocaval fistula attenuates induced pulmonary hypertension in rats, lowering pulmonary pressures and neointimal formation.
Why the study?
Does a surgical aortocaval fistula attenuate monocrotaline-induced pulmonary hypertension in rats?
RCT
Single-blind
Randomized
No
Does a surgical aortocaval fistula attenuate monocrotaline-induced pulmonary hypertension in rats?
p-value: p=<0.001
In a rat model, creating a surgical aortocaval fistula attenuated rather than worsened monocrotaline-induced pulmonary hypertension.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for shunt effects in experimental PH; does not support clinical translation or practice change.
Nishimura et al. (2003) conducted an RCT in Monocrotaline-induced pulmonary hypertension. Surgical aortocaval fistula vs. Monocrotaline and/or pneumonectomy without aortocaval fistula was evaluated on Mean pulmonary arterial pressure (p=<0.001). A surgical aortocaval fistula attenuated monocrotaline-induced pulmonary hypertension in rats, leading to lower mean pulmonary arterial pressure (P<0.001) and less neointimal formation (P=0.034).
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