Key result
Isolated high home SBP is linked to higher diabetic nephropathy risk in T2D patients.
Why the study?
The association between isolated high home systolic blood pressure and diabetic nephropathy risk had not been previously assessed in the medium to long term.
Does isolated high home systolic blood pressure increase the risk of diabetic nephropathy in patients with type 2 diabetes mellitus?
Cohort (n=424)
Does isolated high home systolic blood pressure increase the risk of diabetic nephropathy in patients with type 2 diabetes mellitus?
p-value: p=0.02
Isolated high home systolic blood pressure is a useful prognostic marker associated with an increased risk of progression to diabetic nephropathy over 5 years in patients with type 2 diabetes.
Supports home SBP monitoring for nephropathy risk stratification in T2DM; leaves open whether intervention alters progression.
BACKGROUND: A previous 2-year cohort study has shown that isolated high home systolic blood pressure (IH-HSBP) may increase the risk of diabetic nephropathy, using normal HBP as a reference. However, this association has not been previously assessed in the medium to long term. METHODS: This prospective 5-year cohort study of 424 patients, with normal or mildly increased albuminuria, investigated the effect of IH-HSBP on the risk of diabetic nephropathy in patients with type 2 diabetes mellitus. Diabetic nephropathy was defined as an advancement from normal or mildly increased albuminuira to moderate or severely increased albuminuria. RESULTS: = 0.02). The odds ratio for developing nephropathy in patients with IH-HSBP younger than 65 years was higher than that in patients with IH-HSBP older than 65 years. CONCLUSION: IH-HSBP was associated with an increased risk of diabetic nephropathy among type 2 diabetes mellitus patients with normal or mildly increased albuminuria in the medium to long term. The results support and strengthen previous reports. These findings suggest that IH-HSBP might be a useful marker in disease prognostication.
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Kitagawa et al. (2021) conducted a cohort in Type 2 diabetes mellitus (n=424). Isolated high home systolic blood pressure (IH-HSBP) vs. Normal home blood pressure was evaluated on Diabetic nephropathy (advancement from normal or mildly increased albuminuria to moderate or severely increased albuminuria) (p=0.02). Isolated high home systolic blood pressure was associated with an increased risk of diabetic nephropathy among type 2 diabetes patients over 5 years (P=0.02).
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