Why the study?
Does sympathetic nervous system activity and beta-adrenoreceptor responsiveness differ between patients with essential hypertension and normal subjects?
Does sympathetic nervous system activity and beta-adrenoreceptor responsiveness differ between patients with essential hypertension and normal subjects?
Essential hypertension is associated with sympathetic overactivity and a progressive, age-related reduction in beta-adrenoreceptor sensitivity, which may contribute to the development of hypertension via unopposed alpha-adrenoreceptor-mediated vasoconstriction.
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May link sympathetic hyperactivity to hypertension; leaves open causal role of beta-adrenoreceptor changes pending longitudinal studies.
Bertel et al. (1980) studied this question.
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