Key result
No change or decrease in left ventricular pre-A pressure after TAVR was independently associated with favorable outcomes for all-cause death and heart failure rehospitalization (P=0.003).
Why the study?
Changes in left ventricular diastolic pressure after TAVR and their relationship with subsequent outcomes remained poorly clarified.
Does a lack of increase in LV pre-A pressure after TAVR improve the composite of all-cause death and rehospitalization for heart failure in patients with severe aortic stenosis?
Cohort (n=509)
Yes
Does a lack of increase in LV pre-A pressure after TAVR improve the composite of all-cause death and rehospitalization for heart failure in patients with severe aortic stenosis?
p-value: p==0.003
A lack of increase in left ventricular pre-A pressure after TAVR is associated with better long-term clinical outcomes, which may help identify patients who maximally benefit from the procedure.
May aid post-TAVR risk stratification; leaves open whether LV pre-A pressure is causal or modifiable.
Changes in left ventricular (LV) diastolic pressure after transcatheter aortic valve replacement (TAVR) or their relationship with subsequent outcomes remain poorly clarified. Accordingly, we aimed to assess the changes in invasively measured LV diastolic pressure and their relationship with long-term outcomes in patients undergoing TAVR. METHODS: In total, 509 patients with severe aortic stenosis who underwent TAVR at 3 tertiary centers were retrospectively included and divided into 2 groups according to changes in LV pre-A pressure after TAVR: Group 1, with no change or decrease in pre-A pressure, and Group 2, presenting an increase in pre-A pressure after TAVR. The primary outcome was a composite of all-cause death and rehospitalization for heart failure. RESULTS: =0.003). CONCLUSIONS: Increase in LV pre-A pressure after TAVR is common, and no change or decrease in LV pre-A pressure after TAVR is independently associated with favorable outcomes. Changes in LV pre-A pressure can help identify patient subsets who will maximally benefit from TAVR.
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Seo et al. (2025) conducted a cohort in severe aortic stenosis (n=509). No change or decrease in LV pre-A pressure vs. Increase in LV pre-A pressure was evaluated on composite of all-cause death and rehospitalization for heart failure (p==0.003). No change or decrease in left ventricular pre-A pressure after TAVR was independently associated with favorable outcomes for all-cause death and heart failure rehospitalization (P=0.003).
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